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截至2022年3月30日，据国家卫健委相关报道[1]：截至3月30日24时，据31个省（自治区、直辖市）和新疆生产建设兵团报告，现有确诊病例28599例（其中重症病例66例），累计治愈出院病例116039例，累计死亡病例4638例，累计报告确诊病例149276例，现有疑似病例18例。累计追踪到密切接触者2306745人，尚在医学观察的密切接触者367516人。病毒肆虐，严重影响社会稳定和经济的发展。
新冠病毒是2019新型冠状病毒的简称，又叫2019-nCoV ，SARS-CoV-2 ，SARS-CoV2。新型冠状病毒和SARS冠状病毒（SARS-CoV）是同一类，但不是同一种。基因为单链RAN[2]。目前成熟的新冠病毒检测方法包括胶体金法、荧光免疫层析法、酶联免疫法、化学发光法等等。为了方便大家阅读，小编搜集整理各方法的原理，让大家一文读懂各种检测方法的原理。
DNA甲基化模式的异常往往与癌症发展相关，但并不是打开或关闭一个基因那么简单。例如，超甲基化抑制了抑癌基因，而整体低甲基化则刺激了某些癌基因的表达。在此，我们将介绍一些工具和技术，可方便研究人员分析DNA甲基化在癌症中的作用。
Journal: Food Science and Human Wellness, Vol. 12, No. 5, pp. 1526-1537
2024-07-26
Studies have shown that cannabinoid CB2 receptors are involved in wound repair, however, its physiological roles in fibrogenesis remain to be elucidated. In the present study, the capacity of cannabinoid CB2 receptors in the regulation of skin fibrogenesis during skin wound healing was investigated. To assess the function of cannabinoid CB2 receptors, skin excisional BALB/c mice were treated with either the cannabinoid CB2 receptor selective agonist, GP1a, or antagonist, AM630. Skin fibrosis was assessed by histological analysis and profibrotic cytokines were determined by immunohistochemistry, immunofluorescence staining, reverse transcription‑quantitative polymerase chain reaction and immunoblotting in these animals. GP1a decreased collagen deposition, reduced the levels of transforming growth factor (TGF)‑β1, TGF‑β receptor I (TβRI) and phosphorylated small mothers against decapentaplegic homolog 3 (P‑Smad3), but elevated the expression of its inhibitor, Smad7. By contrast, AM630 increased collagen deposition and the expression levels of TGF‑β1, TβRI and P‑Smad3. These results indicated that cannabinoid CB2 receptors modulate fibrogenesis and the TGF‑β/Smad profibrotic signaling pathway during skin wound repair in the mouse.
2023-02-23
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